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In the absence of amino acids such as cystine, cells promote translation of ATF4 via the general control non-repressor 2 (GCN2) -eukaryotic initiation factor (eIF2a) signaling pathway, which promotes transcription of genes involved in amino acid metabolism and stress response, including SLC7A11, enabling cells to cope with amino acid starvation
This might allow the bodys detoxification and excretory systems to catch up [11]
Biopharm Drug Dispos 19(7):465472 Meiqun C, Gui Z, Kehuan S, Zhengzhi W (2011) Application of bioinformatics technique to screen of differentially expressed proteins in serums of breast cancer patients with white and yellow coating
Weight reduction, improved glycemic control, and cardiovascular protection are meaningful outcomes for patients with type 2 diabetes and obesity
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